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Cerebrovascular Activity of Pikamilon in
the post Ischemic Period
[Article in Russian]
Pharmaceutical Institute,
Kalinin's prosp., 11, Pyatigorsk, 357533, USSR
Abstract
Antihypoxic properties of
pikamilon on white rats and cats under narcosis have been studied.
Cerebrum metabolism induced were determined during the experiment. It has been established that preliminary administration of
pikamilon in the dose of 55 mg/kg increased the percentage of animal survival after circulatory hypoxia, promoted reduction and stimulation of glucose and oxygen utilization processes, decreased the-intensity of cerebral blood flow and increased the functional cerebrovascular stability towards acute hypotension, influenced positively on cerebrovescular autoregulatory reactions in the
postischemic period.
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