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Microvascular Effects of Pikamilon in the
Cortex
[Article in Russian]
Institute of Pharmacology,
Baltiyskaya st., 8, Moscow, 125315, USSR
Abstract
Pikamilon when locally applied at a dose of 0,2 ml of 5% solution was found to induce the dilatation of pial arterioles.
The most pronounced dilatation was observed in vessels with the initial diameter of 10-20 nm. With arteriole diameter being increased the dilatatory effect of the drug diminished.
When differently administered pikamilon causes the increase in cortex blood flow in conscious rats and rabbits.
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